Focus on Continuous Training for On-Call Pharmacists : Tailored Resources and Personalized Training for Safe Validation and Manufacturing of Cytotoxic Products

Introduction
Pharmaceutical coverage for oncological therapeutic emergencies is crucial for managing conditions such as acute leukemias, small cell lung cancers, and macrophage activation syndrome. In 2022 and 2023, 600 to 700 preparations per year were handled in our Cytotoxic Reconstitution Unit (URC) outside regular working hours by on-call pharmacists (ocP) across all pharmaceutical sectors. Initial training (IT) which includes a theoretical component (presentation of the CHIMIO^® software) and a practical component (manufacture) is provided for ocP authorization, along with continuous training (CT).
This work aims to review the available CT ressources and improve their content in response to recent developments in our unit and in line with good preparation practices.

Materials and Methods
In 2020, a study was conducted in our URC to assess the competencies and knowledge of 15 ocPs who had already received IT. Challenges related to the use of the CHIMIO^® software were highlighted, as most pharmacists work in other sectors than the URC. A self-assessment questionnaire revealed that for nine out of 15 critical software steps, ocP felt only initiated or novice despite the IT.
To address these issues, various continuous training resources were created, updated and implemented.

Results
In February 2024, with the update to version 6 of the software, the initial tutorial videos explaining critical steps of pharmaceutical validation and manufacturing were updated by recording short sequences with Screenpresso^® on the CHIMIO^® test environment and then editing them with Canva^®. These videos cover topics such as how to apply a standard dose, modify a prescription dose, change the batch number of a vial, and recreate an identical preparation
To facilitate personalized training, we set up slots on the RDV360 online appointment platform, with 1.5-hour sessions available every two weeks from the beginning of the second quarter of 2024. Eight slots have been reserved so far, with generally positive feedback.
Additionally, a biannual newsletter was instated to inform ocP of major updates in the pharmacotechnology sector : the first edition of 2024 covered the number of on-call movements and preparations made in 2022 and 2023 ; and the recognition of standardized doses (labeling) and their nominal reassignment.

Discussion-Conclusion
The 2020 study concluded that ocP were dissatisfied with their level of training. Based on this observation, the introduction of tutorial videos was well-received by all ocP, who found them clear and meeting their needs, being accessible at any time.
A new satisfaction survey is underway regarding the new tutorial videos, the quality of personalized training and the newsletter.

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