Simulation of a worst case scenario of cytotoxic chemotherapy production without informatics data processing

9 October 2015

L. Gabriel, E. Canton, V. Guarino, V. Lauby Centre Hospitalier de Troyes,
101 avenue Anatole France,
10003 TROYES


Informatics data processing is a major lock in securing production of chemotherapies. In a major informatics disruption, establishment of a degraded procedure should guarantee usual levels of quality and safety. The process including production management documents and a thesaurus of information on protocols and molecules is required. Procedure and related documents have been evaluated and tested in simulation.

Procedure and related documents were evaluated by all pharmacy technicians (PT). Degraded Steps of the procedure are :

  • Dose calculations and manufacturing form completed by the pharmacist;
  • Double check on manufacturing form and labels completed by PT;
  • Double check on labels by the pharmacist
  • Stock management form completed by PT.

Worst case simulation of one hour of production with two PT, controlled by two pharmacists.
Times of preparations, encountered difficulties and critical points were noted.


The elaborate forms were estimated readable and ergonomic, applicable for all types of packaging. Only the stock management form require better readability for the management of bottle remainders. Based on 10 preparations made, an average of 13 additional minutes per preparation was estimated. No differences were observed at the dose calculations.

Discussion and conclusions

In the absence of informatics data processing, the additional preparation time would require the presence of an additional PT. The procedure will be included in the training program and annual reassessment of PT. The informatics data processing eliminates risks of errors related to human, anticipating its interruption is essential. This annual simulation exercise will be extended to complete chemotherapy process integrating care units.

Discussion forum

GERPAC provides for its members a discussion forum specifically devoted to technology in hospital pharmacy

Access forum

Association Loi 1901
Siège social : Chez Jean-Yves Jomier / 8ter rue Léon Bussat, 64000 PAU
Immatriculation formation N° 72 64 035 30 64
Contact us Legal notes - Management of personal data
Réalisation : Développeur web WordPress & SPIP freelance