Review of manual and automated compounding of intravenous drugs : an update in 2017

6 October 2017

J-D. Hecq , C. Decoster, N. Leonard, C. Pirlot, L. Soumoy CHU UCL Namur, site Godinne, 1, avenue Therasse , 5530 Yvoir, Belgium


Automation robots have recently come to the market as an alternative for manual compounding of intravenous (IVD) drugs.


To make a review of manual and automated compounding of iv drugs

Material and methods
A literature review was conducted on the reconstitution of IVD. The following methods were identified: manual, semi automatic and automatic. A classification was carried out in 7 categories: manual syringes, automatic syringes, peristaltic pumps, parental nutrition compounders, compounders for intravenous cytotoxic doses, robots for compounding of intravenous cytotoxic doses, robots for compounding of IVD.

A table describes the different features of each device.
The ampuls can not be supported by these robots. Large dosages vials improve the time of reconstitution compared to current dosage vials. The number of compounding robots is increasing.
Advantages of automated preparation are : higher consistency of process and products, higher accuracy of products, Integrated digitized processing, precise, complete documentation, reduced effort and wrist injuries, reduced personnel requirement, increased worker satisfaction.

Disadvantages of automated preparation are : risk of failure / down time, dependency on power supply, software (updates), high investment costs/High maintenance costs, specialized personnel with additional training, decreased worker satisfaction (early adopter), complexity when products are switched or added, potential for new errors.

This review allows the potential user to know the current availability on the market.

Discussion forum

GERPAC provides for its members a discussion forum specifically devoted to technology in hospital pharmacy

Access forum

Association Loi 1901
Siège social : Chez Jean-Yves Jomier / 8ter rue Léon Bussat, 64000 PAU
Immatriculation formation N° 72 64 035 30 64
Contact us Legal notes - Management of personal data
Réalisation : Développeur web WordPress & SPIP freelance