Practical biopharmaceutics

Using examples including paediatric formulations, food and gastric pH effects, crushed tablets and oral peptide medicines, the presentation shows why the formulation can be as important as the active drug. It also explores emerging predictive approaches—including biorelevant dissolution testing, TIM gastrointestinal models, PBPK modelling and digital twins—which aim to anticipate clinical performance before studies begin.

Key takeaway: understanding a medicine’s journey from formulation to patient can help explain differences in exposure, efficacy, safety and therapeutic response.