2015 Conference

18th GERPAC Conference
13th European GERPAC
Pharmaceutical Technology: Quality & Security
Octobre 7-9, 2015 - Presqu’île de Giens - Hyères

Opening ceremony

Oral preparations and prepared oral unit dose

Microbial contamination

Chemical contaminations

Surface contamination results of a multicenter European study P. Sessink1, S. Crauste-Manciet2 1 Exposure Control Sweden AB
2 Bordeaux University Hospital - Bordeaux University
Pilot study of biological monitoring of four antineoplastic drugs among Canadian healthcare workers C. Poupeau1, C. Tanguay2, C. Plante3, N.J. Caron4, JF. Bussières5 1 D.Pharm. candidate, Research assistant, Pharmacy Practice Research Unit, CHU Sainte-Justine, Montréal, Québec, Canada
2 B.Sc., M.Sc., Coordinator, Pharmacy Practice Research Unit, CHU Sainte-Justine, Montréal, Québec, Canada
3 Inf, conseillère en soins infirmiers, CHU Sainte-Justine, Montréal, Québec, Canada
4 Ph.D, Centre de toxicologie du Québec, Institut national de santé publique du Québec, Québec, Canada
5 B.Pharm., M.Sc., FCSHP, MBA, chef, Département de pharmacie et Unité de recherche en pratique pharmaceutique, CHU Sainte-Justine, professeur adjoint de clinique, Faculté de pharmacie, Université de Montréal, Montréal, Québec, Canada
New NIOSH guidelines on reproductive risks associated with hazardous drug exposures in healthcare workers: Recommendations for reducing exposures T. H. Connor1, C. C. Lawson2 1 PhD, Division of Applied Research and Technology
2 PhD, Division of Surveillance, Hazard Evaluations and Field Studies
National Institute for Occupational Safety and Health, Cincinnati, OH USA
Water micropollutants in Bordeaux area: Strategy for reducing the contamination in an urban territory D. Granger Project manager, SUEZ

Hot topics in pharmaceutical technology

Short oral communications

Medical and Pharmaceutical cooperation as a contributor to the success of pediatric allogeneic hematopoietic stem-cell transplantation (allo-HSCT): inclusion process ability via the therapeutic drug monitoring (TDM) of busulfan (Bu) A. Lalli1, A. Amin1, F. Vidal1, S. Poil1, E. Fonsat1, B. Neven2, M-L. Fremond2, E. Elkaim2, M. Castelle2, S. Blanche2, Ph. Bourget1 1 Service de Pharmacie Clinique,
2 Service Unité d’Immuno-Hématologie et Rhumatologie Pédiatrique,
HU Necker-Enfants Malades - 149 rue de Sèvres, 75015 Paris, France
Determination of the microbiological stability of intrathecal chemotherapy G. Binson1, L. Danguy des Déserts1, A. Bousseau2, A.-C. De Boisgrollier1, I. Princet1 1 Pharmacie – Unité de Reconstitution des Cytotoxiques - CHU de la Milétrie - Poitiers, France
2 Unité d’Hygiène hospitalière - CHU de la Milétrie - Poitiers, France
Preventing workers contamination during solid oral doses repackaging : Why and How? A. Sgarioto1, H. Ginestet1, S. Armand-Branger2 1 Pharmacie à Usage Intérieur - HIA du Val de Grâce, Paris
2 Pharmacie à Usage Intérieur - CESAME, Sainte Gemmes sur Loire
Preparation of frozen stool suspensions for fecal microbiota transplantation M. Jobard, C. Madaoui, O. Fabre, M.L. Brandely, R. Batista, F. Chast Service de Pharmacie, GH Hôpitaux Universitaires Paris Centre,
site Hôtel-Dieu, 1 place du Parvis Notre Dame, 75004 Paris, France
Contribution of the pharmaceutical expertise to the extemporaneous shaping of special catheters for intracerebral injections (ICI) during neurosurgical procedures: application to three clinical trials of gene therapy (GT) in the setting of serious metabolic diseases R. Loeuillet1, A. Amin1, C. Violain1, S. Teixeira1, V. Afonso1, N. Thromas1, M. Tardieu3, M. Zerah2, P. Aubourg2, C. Sevin2, T. Baugnon3, R. Crystal4, K. Belahreche1, V. Zaugg1, C. Broissand1, P. Bourget1 1 Service de Pharmacie Clinique, HU Necker-Enfants Malades, Paris, France
2 Service de Neurologie Pédiatrique - Centre de Référence des Leucodystrophies, Hôpital Bicêtre, Paris, France
3 Service Anesthésie-Réanimation-SAMU-SMUR, HU Necker-Enfants Malades, Paris, France
4 Weill Cornell University, Department of Genetic Medicine, New-York, NY, USA
Integrity testing for sterile preparation syringes A. Pilon1, A.C Gairard Dory1, L. Belotti2, J. Bourbon1, B. Gourieux1 1 Service de pharmacie-stérilisation
2 Laboratoire d’hygiène
Hôpitaux Universitaires de Strasbourg - France
Evaluation of physical constraints related to the use of medical devices during the cytotoxic compounding C. Roch1, N. Martelli1, J. Vernois2, D. Pradeau3, E. Caudron1,4 1 Service Pharmacie, Hôpital européen Georges Pompidou, AP-HP, France
2 Unité Qualité et Essais Hospitaliers, AGEPS, AP-HP, France
3 Laboratoire de Physico-chimie, AGEPS, AP-HP, France
4 Laboratoire de chimie analytique Lyp(Sys)2, Université Paris Sud, France
Differences in disinfection protocols of raw material vials intended to the production of parenteral nutrition mixtures C. Humbert, C. Cros, F. Nadji, J. Bordenave, G. Benoit Hôpital Armand Trousseau, 26, avenue du Docteur Arnold-Netter, 75012 Paris, France
Operational qualification of an automated compounding device of parenteral nutrition : Medimix® IMF M. Garcès, R. Vazquez, MN. Guerrault-Moro, A. Durand Pharmacie - Pharmacotechnie, Centre Hospitalier Intercommunal de Poissy Saint-Germain-en-Laye,
Saint-Germain-en-Laye, France
Validation of the BacT/Alert® method for microbiological control of pediatric parenteral nutrition (PPN) mixtures C. Le Roy1, E. Bermudez1, N. Carre1, C. Chanat1, C. Castelain1, H. Poutet2, M.L. Brunet1, F. Chastv 1 Pharmacy department
2 Bacteriology department
Hôpitaux Universitaires Paris Centre Cochin Broca Hôtel-Dieu,
27 rue du Faubourg-Saint-Jacques, 75014 Paris, France
Contamination of calcium gluconate solutions by aluminum: which consequences for parenteral nutrition in neonatology? B. Raspaud, A. Venet, A. Jourand, S. Mesli, J. Grellet, D. Breilh, S. Crauste-Manciet CHU de Bordeaux, Matrice Pharmacotechnie,
Pôle des produits de Santé, Bordeaux, France
A single fluorescein-combined media fill test for validation of good practices concerning both radiopharmaceutical preparations asepsis and radioprotection A-S. Chantry, C.F. d’Andon, A. Gouillet, Ph. Garrigue, B. Guillet Radiopharmacie AP-HM,
Hôpital Nord, Marseille
Stability assessment of Teicoplanin infusions in 0.9% sodium chloride in various infusion devices J. Holden Quality Control North West, Stepping Hill Hospital, Stockport, UK
Viability of selected microorganisms in non-cytotoxic aseptic preparations I. Sarakbi, I. Krämer Department of Pharmacy, University Medical Center Mainz,
Johannes Gutenberg-University,
Langenbeckstraße 1, 55131 Mainz, Germany
How and why did we set up a Controlled Atmosphere Area of errors ? V. Klaczynski, A. Beausir, C. Fournier Centre Hospitalier de Lens, France Impact of operators and pharmaceutical operations on air quality of controlled atmosphere areas S. Filali, B. Darricau, C. Bretagnolle, E. Diouf, D. Salmon, M.L. Tall, C. Pivot, F. Pirot Pharmacie, Hôpital Édouard Herriot,
Lyon, France
Stability study of a 10 mg/ml concentrated solution of doxorubicin M. Boutet1, T. Briot1,2, S. Vrignaud1, F. Lagarce1,2 1 CHU Angers, service pharmacie, Angers, France
2 L’université Nantes Angers Le Mans, INSERM U1066, Micro et nanomédecines biomimétiques,
Angers, France
Cytotoxic contamination level follow-up during the implementation of an automated compounding system N. Creus1, C. Lopez Cabezas1, M. Oliveras2, G. Cajaraville3, N. Telleria4 1 Hospital Clinic, Barcelona
2 Hospital Vall d’Hebron, Barcelona
3 Onkologikoa, San Sebastian
4 KIRO Robotics S.L. Spain
Study of environmental contamination in the pharmacy and oncology departments of the Institut Curie T. Rusu, J. Fouque, F. Cartier, S. Thevenet, L. Escalup Pharmacie Institut Curie,
Paris, France
Isolator: Does a break of containment leads always to a break of sterility ? E. Sigward, X. Breton, C. Mannechin, P. Faure, N. Jourdan Unité de préparation des anticancéreux
Service Pharmacie CHU Saint-Louis, Paris
Stability of 25 mg/mL 5-azacitidine suspensions kept in fridge after freezing C. Balouzet, C. Chanat, M. Jobard, M-L. Brandely-Piat, F. Chast Service de Pharmacie, GH Hôpitaux Universitaires Paris Centre
Site Hôtel Dieu, 1 place du Parvis Notre-Dame
75004 Paris, France
Evaluation of a new quality-control system for cytotoxics based on UV-visible spectrophotometry (DrugLog®) F. Feutry1,2, A. Exquis2,3, L. Falaschi2, N. Guichard2,3, P. Odou1, P. Bonnabry2,3, S. Fleury2 1 UDSL, EA GRITA, Univ Lille, 3 rue du Professeur Laguesse, F-59000, Lille, France
2 Pharmacy, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil CH-1211 Geneva 14, Switzerland
3 Section of pharmaceutical sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
New approach for rapid, non-invasive and non-destructive quantification by near infrared spectroscopy (NIRS): Application to amoxicillin infusion L. Lê1,2, L. Eveleigh3, P. Prognon1,2, E. Caudron1,2 1 Université Paris Sud, Groupe de Chimie Analytique Paris Sud, Lip(Sys)², Chatenay Malabry, France
2 Hôpital Européen Georges Pompidou (AP-HP), Service de Pharmacie, Paris, France
3 AgroParisTech, INRA, Laboratoire de Chimie Analytique, Paris, France
Identification of 1ml and 3ml syringes by video camera to control drug compounding M. Henriquet, E. Fougereau, F. Benizri Institut Paoli Calmettes,
Marseille, France
Pilot project of RFID tags suitable for tracking cancer chemotherapy preparations M. Lafay-Bourquin, C. Giard, J. Rambaud, I. Ferry, L. Escalup Institut Curie - Hôpital René Huguenin, service Pharmacie, 35 rue Dailly
92210 Saint-Cloud, France

Workshops

posters

A stability study of 25 mg/mL phenylephrine hydrochloride and 5 mg/mL tropicamide eye drops F. Stordeur, C. Chanat, M-L. Brandely-Piat, F. Chast Pharmacy unit, GH Paris Centre, site Hôtel-Dieu, AP-HP,
1 place du Parvis Notre Dame, 75004 Paris, France
Repackaging of sterile empty bottles for eyedrops preparation S. Filali, C. Bretagnolle, B. Darricau, D. Salmon, M.L. Tall, E. Diouf, C. Pivot, F. Pirot Pharmacie, Hôpital Édouard Herriot, Lyon, FRANCE
Standard parenteral nutrition stability study C. Grignon1,2, JB. Monteil1, K. Waton1, K. Beuzit1, K. Husseini3, A. Dupuis1,2 1 Pharmacy, Poitiers University Hospital
2 Pharmacy Faculty, University of Poitiers
3 Pediatrics department, Poitiers University Hospital, France
Multidisciplinary Workgroup for the Improvement of preparation practices for parenteral nutrition D. Betton1, M. Leduc1, M.E. Moulies2, Y. Gauquelin1, C. Fijalkowski1, V. Guillemin1 1 Pharmacie
2 Néonatalogie
Centre Hospitalier Territorial de Nouméa
BP J5 98849 Nouméa cedex, Nouvelle-Calédonie
Study of the impact of a multi coat packaging on the stability of the parenteral nutrition mixtures D. Laleye1, P. Cerf1, A. Traoré1, W. Mos1, ML. Tall1, E. Diouf1, C. Barreto1, F. Pirot1,2, C. Pivot1 1 Pharmacie, Groupement Hospitalier Edouard Herriot, 5 place d’Arsonval, 69437 Lyon cedex 03, France
2 Laboratoire de Recherche et développement de Pharmacie Galénique Industrielle,
Faculté de Pharmacie, EA 4169 "Fonctions Physiologiques et Pathologiques de la Barrière Cutanée",
Université Claude Bernard Lyon 1, 8 avenue Rockefeller, 69373 Lyon cedex 08, France
An a priori analysis of the risks on the manufacturing process of customized parenteral nutrition bags (NP) at the Rennes University Hospital L. Ruesche1, P-N. Boivin1, M-A. Lester1, S. Morille2, P. Le Corre1 1 Pharmacotechnie, Pôle Pharmacie
2 Direction Qualité et Relations Usagers
CHU de Rennes, 2 Rue Henri le Guilloux, 35000 Rennes, France
Microbiological validation of aseptic injectables preparations (AIP) manufacturing process thanks to a validation kit M. Barral, C. Fayard, C. Martin, F. Serratrice Métropole Savoie Hospital
49, Avenue du Grand Port Aix les Bains, France
Tél: +33 6 59 69 79 42
Analytical control of cytotoxic preparations: development of a pedagogical analysis tool J. Rambaud1, M. Lafay1, I. Ferry1, L. Escalup2 1 Hôpital René Huguenin - Institut Curie, 92210 Saint-Cloud
2 Institut Curie, 75006 Paris, France
Manual or semi-automatic small batch preparation of chemotherapy: witch process is choose by the team? M. Moine, C. Ménard, D. Sankhare, G. Ventroux, V. Breteau, P. Faure, N. Jourdan Saint-Louis Hospital, anticancer preparation unit, 75010 Paris, France Subcutaneuous trastuzumab : any fears ? any new practices ? M. Rauturier, P. Feïstl, D. Lemoine, S. Truet Pharmacie, CH Bayeux, 13 rue Nesmond, 14400 BAYEUX, France
Cytotoxic Surface Contamination in a Chemotherapeutic Preparation Unit: Method Development H. De Blander, A. Facchin, S. Edet, A. Sarrazin, A. Jacolot, M. Rigal, C. Padoin Unité de Préparation et de Contrôle des Chimiothérapies anticancéreuses
Pharmacie, Hôpital Avicenne, HUPSSD, AP-HP, Bobigny
Control of chemotherapy preparations: gravimetry in process versus FIA - application to 5FU M. Martin, C. Fercocq, M. Choquet, R. Linossier, J-L. Pons, J-M. Descoutures Service pharmacie, Centre Hospitalier Victor Dupouy,
69 rue Lt-Cl Prudhon, 95107 Argenteuil, France
Interest of analysing data gathered by a chemotherapy drugs compounding real-time video control solution for pharmaceutical technicians training and monitoring CH. Blancher, M. Laplace, B. Dalifard, B. Le Franc, MA. Cadeac Pharmacie, Groupe Hospitalier La Rochelle Ré Aunis,
La Rochelle, France
In vitro tests of intraperitoneal chemotherapy new delivery device A. Nierenberger1, N. Vantard1, D. Salmon3,4, O. Glehen5, M. Alyami5, F. Ranchon1,2, V. Schwiertz1, D. Cabelguenne1, F. Pirot3,4, C. Pivot4, C. Rioufol1,2 1 Clinical Oncology Pharmacy Department, Hospices Civils de Lyon, Lyon Sud Hospital, France
2 EMR UCBL/HCL 3738, Université Claude Bernard Lyon 1, Lyon, France
3 EA 4169, Université Claude Bernard Lyon 1, France
4 Unité de préparation et contrôle des médicaments, Hôpital Edouard Herriot, Hospices Civils de Lyon, France
5 Surgical Department, Hospices Civils de Lyon, Lyon Sud Hospital, France
Cisplatin hydration: review and optimization of clinical practice I. Trinh1, A. Mairovitz2, L. Bouaita3, J. Dos-Reis1, E. Bezian1, C. Martin1, T. Cohen1 1 Pharmacie et stérilisation
2 Pneumologie-oncologie
3 Oncologie
CHI de Villeneuve-Saint-Georges Lucie & Raymond Aubrac, 40 allée de la Source, 94195 Villeneuve-Saint-Georges
Simulation of a worst case scenario of cytotoxic chemotherapy production without informatics data processing L. Gabriel, E. Canton, V. Guarino, V. Lauby Centre Hospitalier de Troyes,
101 avenue Anatole France,
10003 TROYES
The computerization of Paediatric Hematology oncology protocols is it possible? State of play of computerization in the reference centers of the French Society of cancers of the Child (SFCE) D. Couderc, A. Jourand, A. Venet, Y. Perel, J. Grellet , D. Breilh Pôle produit de Santé
CHU de Bordeaux,
33076 Bordeaux, France
Stability study of an injectable hospital preparation of naloxone hydrochloride as part of a clinical trial ML. Tall1, EH. Diouf1, D. Laleye1, C. Dhelens1, M. Lenfant1, B. Ducarre1, N. Koog1,D. Salmon1,2, F. Pirot1,2, C. Pivot1 1 Pharmacie, Groupement Hospitalier Edouard Herriot, 5 place d’Arsonval, 69437 Lyon cedex 03, France
2 Laboratoire de Recherche et développement de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, 8 avenue Rockefeller, 69373 Lyon cedex 08, France
To improve securitization of drug use process: computerized prescription and Nominative Automated Drug Dispensing (NADD) M. Martin, C. Favier, G. Sujol, S. Bedjidian, S. Baudry-Colomes Pharmacie, GCS Pharmacoopé, Centre Hospitalier Léon-Jean Gregory, Thuir 
Qualification of a shielded class A hot cell for the preparation of radiopharmaceutical drugs I. Le Borgne, L. Masson, H. Larbre, JB. Rey Institut Jean Godinot, CLCC of Reims, France
isabellelb78220@gmail.com, laurent.masson@reims.unicancer.fr, helene.larbre@reims.unicancer.fr, jean-baptiste.rey@reims.unicancer.fr
Optimizing the automated preparation of the experimental 68Ga-DOTATATE radiotracer J. Leenhardt, I. Bennegueouche, Ph. Garrigue, B. Guillet Radiopharmacie AP-HM, Hôpital Nord, Marseille

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