In vitro tests of intraperitoneal chemotherapy new delivery device

A. Nierenberger1, N. Vantard1, D. Salmon3,4, O. Glehen5, M. Alyami5, F. Ranchon1,2, V. Schwiertz1, D. Cabelguenne1, F. Pirot3,4, C. Pivot4, C. Rioufol1,2 1 Clinical Oncology Pharmacy Department, Hospices Civils de Lyon, Lyon Sud Hospital, France
2 EMR UCBL/HCL 3738, Université Claude Bernard Lyon 1, Lyon, France
3 EA 4169, Université Claude Bernard Lyon 1, France
4 Unité de préparation et contrôle des médicaments, Hôpital Edouard Herriot, Hospices Civils de Lyon, France
5 Surgical Department, Hospices Civils de Lyon, Lyon Sud Hospital, France

Aim

Intraperitoneal chemotherapy (non-hyperthermic) is a new local treatment strategy in case of unresectable peritoneal carcinomatosis, which showed encouraging results allowing resactability in the most favorable cases. Platinum salts or taxane based chemotherapy are injected into the peritoneal cavity and stay in until physiological elimination. The issue of this strategy is to ensure uniform chemotherapy drugs diffusion into the peritoneal cavity. The aim of this study is to test in vitro chemotherapy diffusion through a new specific medical device made of two multi-perforated intraperitoneal silicone catheters (80cm) mounted on a double Port-A-Cath (DISTRICATH®605 PM-L, DISTRICLASS, ST ETIENNE, FRANCE).

Methods

The chemotherapy viscosity may impact on the diffusion; a measure by rheometer was done for four different solutions: NaCl 0.9% (the best case), glucose 30% (the worst case), carboplatin 1mg/mL and paclitaxel 0.1mg/mL. A diffusion study was done with NaCl 0.9% in real condition of use according to the mounting of medical devices planned for the administration. The addition of a marker (Patent blue V) enabling us to measure the diffusion in proximal, middle or distal section of the two catheters by marker’s dosage at different times with UV/visible spectroscopy.

Results

Anticancer drugs tested at therapeutic concentration don’t increase the viscosity of the dilution solute. Marker’s concentrations reveal a linear increase in the three sections of the two catheters. No catheters’ obstruction was observed.

Discussion and conclusion

About the diffusion, in vitro results show that the new device provides an interesting solution to administer anticancer chemotherapy into the peritoneal cavity; however this study doesn’t reproduce or simulate the real intraperitoneal environment. The next step will be to test this medical device in vivo.

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