2016 Conference

19th GERPAC Conference
14th European GERPAC
Pharmaceutical Technology and risk management in hospital pharmacies
Octobre 5-7, 2016 - Presqu’île de Giens - Hyères

Automation group for ready to administer oral forms

Parenteral nutrition admixtures

Hot topics in hospital pharmaceutical technology (1)

Chemical contamination

GERPAC study phase 2: Surface contamination in control laboratories P. Sessink1, S. Crauste-Manciet2 1 Exposure Control
2 Bordeaux University Hospital - Bordeaux University
Surface contamination in homes of home-care patients R. Schierl, Y. Sverdel Institute for Occupational, Social and Environmental Medicine,
University Munich (LMU), Germany (rschierl@med.lmu.de)
Safe handling of cytotoxic drugs in low and middle income countries: How to progress? S. von Grünigen1, P. Bonnabry1,2 1 Pharmacy, University Hospitals of Geneva, Geneva (HUG), Switzerland
2 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
Occupational exposure and contamination to antineoplastic drugs of healthcare workers in developing countries, such as Mauritania M. Canal-Raffin1, B. Martinez2, M. Mohamedou3, F. Pilliere4, A. Leclercq5, K. Titier6, M. Molimard1, M. Cheikh EL Moustaph Sidatt7 1 PharmD, PhD. Laboratoire de Pharmacologie Clinique et de Toxicologie, CHU Bordeaux,
Université de Bordeaux, INSERM 1219, France
2 INSERM 1219, Bordeaux, France
3 MD. Directeur Général du Centre National d’Oncologie, CNO, Professeur à la faculté de médecine de Nouakchott. Mauritanie
4 MD. Institut National de Recherche et de Sécurité, INRS. Département Etudes et Assistance Médicales, Paris, France
5 PharmD. Laboratoire Cerba, Saint Ouen d’Aumône, France
6 PharmD, PhD. Laboratoire de Pharmacologie Clinique et de Toxicologie, CHU Bordeaux, France
7 MD. Chef de Service technique, Office National de la Médecine du Travail (ONMT), Nouakchott, Mauritanie

20. Hot topics in hospital pharmaceutical technology (2)

Short oral communications

Input of LEAN methodology to day care unit (HDJ) and cytotoxic production unit (UPAC): patient care pathway improvement L. Escalup1, A. Hurgon1, A. Chastang1, ML. Moulard1, N. Harlez1, J. Pradelle2, C.Roussel2, P Cottu1 1 Institut Curie, Paris, France
2 3M France
Application of Lean methodology to the pre-production stage in a preparation unit of cytotoxic drugs J. Daupin1, H. Aboudagga1, N. Valin1, G. Jaillet1, F. Atout1, E. Caudron1,2 1 Georges Pompidou European Hospital (AP-HP), Pharmacy unit, Paris, France
2 Paris-Sud University, Groupe de Chimie Analytique Paris Sud Lip(Sys)², Chatenay-Malabry, France
Analysis of notified adverse events: a tool for improving risk mapping related to the automatic repackaging and preparation of individual doses M. Cadart , B. Rousset, S. Armand-Branger CESAME (Centre de Santé Mentale Angevin), Ste Gemmes sur Loire,
BP 50089 49137 Les Ponts de Cé Cedex 9, France
Feedback of individual parenteral nutrition production with Logipren® G. Binson1, V. Pigeon1, K.Beuzit1, R. Husseini2, C. Tripon2, C. Grignon1, A. Dupuis1 1 Pharmacie - CHU de Poitiers, 2 rue de la milétrie, 86021 Poitiers
2 Réanimation pédiatrique - CHU de Poitiers, 2 rue de la milétrie, 86021 Poitiers
Implementation of a remote oncology-monitoring program for cancer patients in outpatient care unit E. Peyrilles, K. Sejean, C. Lepage, B. Bonan Service Pharmacie, Hôpital Foch, 40 rue Worth, 92151 Suresnes ISO 9001 certification approach within a cytotoxic preparation unit : the preliminary audit to the implementation of quality management system A. Leherle, L. Baillet, C. Fercocq, R. Linossier, J.-L. Pons Service Pharmacie, Centre Hospitalier Victor Dupouy, Argenteuil, France Stability of midazolam and noradrenaline stored in cyclic olefin copolymer AT-Closed Vials® and polypropylene syringes during 365 days F. Feutry1,3, S. Genay1,2, C. Velghe1, C. Barthélémy1, B. Décaudin1,2, P. Odou1,2 1 Univ. Lille, EA 7365 - GRITA - Groupe de Recherche sur les formes Injectables
et les Technologies Associées, F-59000 Lille, France
2 Pharmacy institute, University Hospital, Lille, France
3Oscar Lambret Centre, Lille, France
Permeability and release of decontaminating agent used in cytotoxic reconstitution units: diffusion of hydrogen peroxide in IV solution container C. Gérard, S. Huguet, K. Rezai, C. Giard, M. Lafay, I. Ferry, L. Escalup Institut Curie, Hôpital René Huguenin - 42 rue Dailly - 92210 Saint Cloud Validation of an ultra-fast microbiological control method for hospital preparations by scanning cytometry C. de Bastiani1, C. Margain1, E. Clerc2, P. Neves2, V. Lebreton1, C. Pivot1, F. Pirot1 1 Groupement Hospitalier Centre - Hôpital Edouard Herriot - Service Pharmacie
Unité Préparation et Contrôle du Médicament - Lyon - France
2 bioMerieux® - Lyon - France
Feasibility study for the installation of a digital video control for anticancer injectable preparations G. Le Roch, C. Guillemot, A. Grand, Y. Cretu, F. Puisset, J-M. Canonge Institut Universitaire du Cancer 1, avenue Irène Joliot-Curie 31100 Toulouse, France Physicochemical stability of Oxaliplatin beta infusion concentrate and infusion solutions in polyethylene bags prefilled with 5% glucose vehicle solution over a 28 day period I. Sarakbi, I. Krämer Department of Pharmacy, University Medical Center Mainz,
Langenbeckstraße 1, 55131 Mainz, Germany
Development of a non-destructive dosage method by Raman spectroscopy, applied to 5-Fluorouracil solutions B. Dectot, N. Simon, M. Vasseur, B. Décaudin, P. Odou Univ. Lille, CHU Lille, EA 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France Which alternative to ticarcillin eye drops ? S. Monirul, M. Jobard, N. Carre, J. Fresneau, M-L. Brandely-Piat, F. Chast Service de Pharmacie, Groupement des Hôpitaux Universitaires Paris Centre,
site Hôtel-Dieu, 1 place du Parvis Notre-Dame, 75004 Paris, France
Candling sterile injectable preparations: an illusion? A. Ifrah, C. Deprez, A. Lebreton, V. Daniel, L. Le Quay, M-A. Clerc Pharmacy Department, University Hospital of Angers, 4 rue Larrey, 49100 Angers, France Galenic impact of a change oral suspension vehicle A. Allainmat-Lemercier1, P. Rault1, P-N. Boivin11, N. Brandhonneur2, P. Le Corre2, M-A. Lester1 1 Pharmacy department, Rennes university Hospital, Rennes, France
2 Laboratory of Pharmaceutics, Biopharmaceutics and Clinical Pharmacy - Faculty of Pharmacy and University Hospital Rennes, University of Rennes 1, Rennes, France
Validation of a semi-automatic vacuum pack machine for batch preparations C. Dupire1, L. Sauvaget1, C. Gary1, V. Servant1, R. Legeron1,2, A. Berroneau1, D. Breilh1,2, S. Crauste-Manciet1,3 1 Pharmaceutical technology department, Bordeaux University Hospital, France
2 Department of Pharmacokinetics, Groupe PK/PD, INSERM U1034 - Bordeaux University Hospital, France
3 Laboratoire ARNA, ChemBioPharm, U1212 INSERM - UMR 5320 CNRS Bordeaux University, France
Terrorist organophosphate (OP) poisoning: pharmaceutical organization for the preparation of an antidotal treatment E. Jandot, E. Diouf, D. Salmon, V. Lebreton, C. Paillet, C. Pivot, F. Pirot Groupement Hospitalier Centre - Hôpital Edouard Herriot - Service Pharmacie
Unité Préparation et Contrôle du Médicament - Lyon, France
What is the best option for double-blind capsule preparation in clinical trials? C. Gary1, S. Djabarouti1,2, A. Venet1, G. Guyon1, P. Mora1, S. Tamisier1, F. Xuereb1,2, S. Crauste-Manciet1,3, D. Breilh1,2 1 Pharmaceutical technology department, Bordeaux University Hospital, France
2 Department of Pharmacokinetics, Groupe PK/PD, INSERM U1034 - Bordeaux University Hospital, France
3 Laboratoire ARNA, ChemBioPharm, U1212 INSERM - UMR 5320 CNRS Bordeaux University, France
Anticancer drugs preparation in the hospital : proposition of tools to help the implementation of dose banding M. Humbert, A-S. Lang, A. Camut, V. Noirez Pharmacie, CHR Metz-Thionville, France Prevention of work related musculoskeletal disorders in pharmaceutical technology F. Reisz1, AC. Gairard-Dory1, K. Fonmartin2, J. Bourbon1, B. Gourieux1 1 Service de Pharmacie
2 Service de Pathologies professionnelles et médecine du travail
Hôpitaux Universitaires de Strasbourg, Strasbourg, France
An isolator of errors: a useful training tool for hospital technicians M. Moine, J.C. Nicoulaud, C. Roux, D. Sankhare, P. Faure, N. Jourdan Saint-Louis Hospital, anticancer preparation unit, 75010 Paris, France Variability of the attention and the perceived workload: analysis by the d2 Test and the NASA Task Load Test of pharmacy technicians in a chemotherapy reconstruction unit M. Lefebvre1, A. Dory1, J. Friedl1, J. Bourbon1, J. Detour1, J. Kemp2, B. Gourieux1 1 Service pharmacie-stérilisation, University Hospital of Strasbourg, France
2 Service de Neuropsychologie, University Hospital of Strasbourg, France
Nouvel Hopital Civil : 1, place de l’hôpital BP 426
67091 Strasbourg Cedex, France - Tél : +33 369550760
Evaluation of Professional Practices: chemical contamination in a antineoplastic agent production unit F. Drapeau, B. Darricau, C Rossard, G. Hoarau, F. Chan-Ou-Teung, S. Rosbicki Pharmacie, UF Pharmacotechnie, CHU Sud Réunion, Saint Pierre Assessment of a continuous education training tool for hospital technicians working in grade A controlled areas M. Teytaud1, A. Colombe1, B. Raspaud1, A. Jourand1, D. Breilh1,2, S. Crauste-Manciet1,3 1 Pharmaceutical Technology Department, Bordeaux university hospital (CHU de Bordeaux), France
2 Laboratoire de Pharmacocinétique et de Pharmacie Clinique - Groupe PK/PD INSERM U1034
3 ARNA ChemBioPharm U1212 INSERM - UMR 5320 CNRS Bordeaux University, France
Automation of a dose banded bortezomib campaign dispensing system D. Lovett Leicester Royal Infirmary

Workshops

Posters

Stability of 1 IU/mL diluted insulin solution: don’t forget the preservatives! S. Genay1,2, F. Feutry1,3, F. Potié1, C. Barthélémy1, B. Décaudin1,2, P. Odou1,2 1 Univ. Lille, EA 7365 - GRITA - Groupe de Recherche sur les formes Injectables et
les Technologies Associées, F-59000 Lille, France
2 Pharmacy institute, University Hospital, Lille, France
3 Oscar Lambret Centre, Lille, France
Validation of drug compounding for intrathecal analgesia V. Pigeon, G. Binson, C. Grignon, A. Dupuis Pharmacie, CHU de Poitiers - 2 Rue de la Milétrie, 86000 Poitiers, France Implementation of Bevacizumab hospital preparation in syringes at hospital pharmacy department: Conducting an internal audit EH. Diouf, Q. Bessonnat, D. Salmon, V. Lebreton, D. Laleye, C. Pivot, F. Pirot Formulation of an oral solution of urea J. Bourbon, C. Duval, A. Dory, M. Fourtage, B. Gourieux Pharmacy and sterilization unit
CHU de Strasbourg, service pharmacie-stérilisation, Nouvel Hôpital Civil : 1, place de l’hôpital
BP426, 67091 Strasbourg Cedex - Tél : 0369550760
Preparation of atropine sulfate syringes (5 mg – 1 ml) as part of terrorist organophosphate (OP) poisoning  E. Jandot, E-H. Diouf, D.Salmon, V. Lebreton, C. Paillet, F. Pirot, C. Pivot Groupement Hospitalier Centre - Hôpital Edouard Herriot - Service Pharmacie
Unité Préparation et Contrôle du Médicament - Lyon, France
Evaluation of Kiro Oncology® robot performances to make bags, syringes and elastomeric pumps of chemotherapy drugs M. Jobard1, M-L. Brandely-Piat1, A. Hurgon2, L. Escalup2, F. Chast1 1 Service de Pharmacie Clinique, Groupe des Hôpitaux Universitaires Paris Centre,
site Hôtel-Dieu, 1 place du Parvis Notre Dame, 75004 Paris, France
2 Service de Pharmacie, Institut Curie, 26 rue d’Ulm, 75005 Paris, France
Single channel pump MediMix® for cytotoxic handling F.A. Chastang, A. Chassin, A. Lalli, A. Hurgon, L. Escalup Curie Institut, Department of Pharmacy, 26 rue Ulm, 75248 Paris Cedex 5 Simulation of the preparation of an injectable anticancer medicine using a Media Fill Test coupled with Fluorescein: a technical validation method of preparation quality J. Soyer, A. Molinier, A. Baudoin, C. Debarre, I. Dherbilly, D. Gueylard Chenevier Pharmacy, Centre Hospitalier Intercommunal du Pays de Cognac, 16100 Cognac, France Study of efficiency of cytotoxic vial biodecontamination into an Oxygen® airlock, using Klercide® product C. Dubegny, P. Labet, C. Audeval, A. Remoue, C. Devys Institut de cancérologie de l’ouest - Centre René Gauducheau, Service pharmacie,
boulevard Jacques Monod, 44800 Saint Herblain, France
The digital eye: an original pharmaceutical technology supporting cytotoxic drug production. Focus on one year of artificial intelligence. E. Girault, M. Laplace, B. Dalifard, B. Le Franc, M-A. Cadeac Service pharmacie, Groupe Hospitalier de la Rochelle-Ré-Aunis,
Rue du Docteur Schweitzer, 17000 La Rochelle, Paris
Validation of a new peristaltic pump for batch production in isolator J. Ollivier1, C. Gary1, L. Sauvaget1, G. Bouguéon1, A. De Coucy1, V. Servant1, A. Berroneau1, D. Breilh1,2, S. Crauste Manciet1,3 1 Pharmaceutical technology department, Bordeaux University Hospital, France
2 Department of Pharmacokinetics, Groupe PK/PD, INSERM U1034 - Bordeaux University Hospital, France
3 Laboratoire ARNA, ChemBioPharm, U1212 INSERM - UMR 5320 CNRS - Université de Bordeaux- Collège et département des Sciences de la Santé
Chemotherapy outsourcing : "supplier-customer" audit M. Cussenot1, A-L. Pouliquen2, Y. Cano Y Gil3, P. Cuny4 1 Hôpital Privé de l’Ouest Parisien, Pharmacie, 14 Avenue Castiglione Del Lago, 78190 Trappes, France
2 Hôpital Privé d’Antony, Pharmacie, 1 rue Velpeau, 92160 Antony, France
3 Hôpital Privé des Peupliers, Pharmacie, 80, rue de la Colonie, 75013 Paris, France
4 Siège Ramsay Générale de Santé, Direction Pharmacie, 96 avenue d’Iéna, 75016 Paris, France
Design of a training and qualification program for hospital pharmacy technicians in pharmacy-compounding sterile preparations A. Colombe1, B. Raspaud1, A. Jourand1, D. Breilh1,2, S. Crauste-Manciet1,3 1 Pharmaceutical technology department, Bordeaux University Hospital, France
2 Department of Pharmacokinetics, Groupe PK/PD, INSERM U1034 - Bordeaux University Hospital, France
3 Laboratoire ARNA, ChemBioPharm, U1212 INSERM - UMR 5320 CNRS Bordeaux University
Management of occupational risk associated with exposure to antineoplastic drugs : regional survey in health institutions with oncology activity M. Giovanelli1, B. Hombourger2, N. Fabié3 H. De Blander, S. Edet, S. Brahmi, A. Jacolot, M. Rigal, C. Padoin 1 Service Pharmacie, CHRU de Nancy, Allée du Morvan , 54511 Vandœuvre-lès-Nancy, France
2 Service Pharmacie, Institut de Cancérologie de Lorraine, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France
3 Réseau ONCOLOR, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France Unité de Préparation et de Contrôle des Chimiothérapies anticancéreuses,
Pharmacie, Hôpital Avicenne, HUPSSD, AP-HP, Bobigny, France
Surface contamination in a Chemotherapeutic Preparation and Control Unit Theoretical training sessions in onco-hematology for hospital technicians M. Moine, D. Sankhare, J.C. Nicoulaud, P. Faure, N. Jourdan Saint-Louis Hospital, anticancer preparation unit, 75010 Paris, France Implementation of a training and authorization program for pharmacy technicians in a Chemotherapies Preparation Unit (CPU) C. Zecchini, G. Mellion, F. Poirot Lutrin, P. Lourman, J. Berlioz Centre Hospitalier Annecy Genevois, Service Pharmacie,
21 impasse des illettes - ZI des îles - 74 370 EPAGNY METZ-TESSY
Implementation of an aseptic processing test under isolator A. Grévy, C. Zecchini, P. Lourman, J. Berlioz Centre Hospitalier Annecy Genevois, Service Pharmacie,
21 impasse des illettes - ZI des îles - 74 370 EPAGNY METZ-TESSY
Hydrochlorothiazide oral suspension 2mg/mL: study of stability in SyrSpend® SF PH4 powder C. Lambert, C. Grignon, A. Dupuis Department of Pharmacy, University Hospital of Poitiers, 2 rue de la Milétrie, 86000 Poitiers, France
Training reinforcement impact evaluation in parenteral nutrition preparation practices within CAA C. Imbert, J. Zerbit, C. Cros, F. Nadji, J. Bordenave, G. Benoit Hôpital Armand Trousseau, 26, avenue du Docteur Arnold-Netter, 75012 Paris, France  An a priori analysis of the risks on the injectable chemotherapy process: the FMECA method A. Bodin, A. Pillier, A. Ifrah, M. Urban, A. Lebreton, L. Le Quay, M.A. Clerc Pharmacie à usage intérieur, CHU - 4 rue Larrey, 49100 Angers, France Implementation of monitoring and evaluation tools for hospital pharmacy technicians (PPH) in an oncology pharmacy unit (UPO) C. Coccini, O. Combes, M. Boissiere, F. Lafaille, M. Knight, JM. Kinowski, C. Cousin Centre Hospitalier Universitaire Carémeau, place du Pr Debré, 30029 Nîmes - France Production’s transfer of lipids ‘syringes from neonatal reanimation unit to the pharmacy: towards standardization of parenteral nutrition’s practices V. Larbre, M. Wasiak, P. Chennell, L. Delaborde, B. Bœuf, M. Jouannet-Romaszko, V. Sautou Hospital-University Center of Clermont-Ferrand, 63000 Clermont-Ferrand, France Interest and economic impact of the development of computer tools for the management and the reallocation of the returned preparations of chemotherapy N. Osman, B. Louveau J.L. Favrat, F. El Kouari, L. Hassani, L. Bekari, P. Tilleul, A. Bellanger Pharmacie - Unité de Pharmacie Clinique en Oncologie Hématologie Hôpital Pitié Salpêtrière,
48 Boulevard de l’hôpital, 75013 Paris, France

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